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Rei Sakuma (佐久間 レイ (さくま れい) Sakuma Rei, born January 5, 1965 in Tokyo, Japan), whose real name is Reiko Sakuma (佐久間 玲子 (さくま れいこ) Sakuma Reiko), is a Japanese voice actress and singer. She is best known for her work in Anpanman, Ranma ½, Azuki-chan, and Onegai My Melody. Sakuma voiced Tsubaki Domyoji in the third installment of the Hana Yori Dango audio drama.

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